However, G2A activation was not sufficient to promote M1-polarization in bone marrow-derived macrophages.

Fittingly, the number of M1-like macrophages was reduced in the inflamed tissue in G2A-deficient mice. G2A-deficient mice showed a reduced zymosan-induced thermal hyperalgesia, which was reversed after macrophage depletion. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-model of acute inflammation. Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. 3Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany.2Project Group Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt, Germany.1Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, Frankfurt, Germany.Schäfer 1 †, Jennifer Cohnen 1, Sandra Pierre 1, Tabea Osthues 2, Neda Tarighi 1, Stefan Hohmann 1, Nerea Ferreiros 1, Bernhard Brüne 2,3, Andreas Weigert 3, Gerd Geisslinger 1,2, Marco Sisignano 1 and Klaus Scholich 1,2 *

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